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Clinical Progress of Glutaminase Inhibitors Glutaminase inhibitors selectively target the overactive GLS in cancer cells, sparing GLS2 in normal cells: Blocking EMT (Epithelial-to-Mesenchymal Transition) : These inhibitors can help prevent EMT, which supports cancer spread

This immune-modulating effect can help reduce neuroinflammation, contributing to improved behavioral outcomes

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Compound 5 (1 g, 0.59 mmol) was dissolved in DCM (2.6 mL) under nitrogen atmosphere and ice bath conditions