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Interestingly, we discovered that such decreases in GSH levels during ferroptosis do not occur immediately on erastin treatment, despite dramatic changes in cellular morphology (Fig

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Mammalian TrxRs are homodimeric selenoenzymes of 55-60 kDa in a head-to-tail conformation, with every subunit containing a flavin adenine dinucleotide, an NADPH-binding domain, and the C-terminal active site motif GCUC