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Competitive binding between dynamic p53 transactivation subdomains to human MDM2 protein: implications for regulating the p53.MDM2/MDMX interaction

10.1016/j.ejphar.2006.01.037 [DOI] [PubMed] [Google Scholar] Niimura M., Takagi N., Takagi K., Mizutani R., Ishihara N., Matsumoto K., et al

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Although senolytics exhibit cell type specificity in targeting senescent cells, their clinical translation remains limited by the absence of standardized biomarkers or universally accepted diagnostic criteria to guide precision interventions

Large differences in the biological half-life and volume of distribution of hydrochlorothiazide in normal subjects from eleven studies

However, several formulations are commercially available as dietary supplements in various international and regional markets (Table 2)