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Direct Adrenergic Agonism: Ephedrine is also able to directly bind to multiple post-synaptic adrenergic receptor subtypes to initiate intracellular signaling cascades: : Activation of vascular smooth muscle 1 -Adrenergic Activation 1 -adrenergic receptors produces arterial and venous vasoconstriction, leading to an increase in systemic vascular resistance (SVR), diastolic blood pressure, and systolic blood pressure (Solanki et al, 2014)

Rural residential areas have continued to expand, indicating a growing trend in continue expansion

Symptoms like headache, confusion, mood changes, seizures, etc

Under conditions of oxidative stress, primarily driven by ROS overproduction, the structural and functional integrity of the BBB becomes severely compromised [38,39,40,41,42,43]

PMID: 25081826

All events should be recorded, evaluated by study staff, and reported according to safety and ethics guidelines