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Tesamorelin (Egrifta/Egrifta SV) is a synthetic GHRH analogue and the only FDA-approved growth hormone-releasing hormone analogue currently marketed in the United States, indicated for visceral fat reduction in HIV-positive patients with lipodystrophy [2], [5]

Once inside adipocytes and other metabolically active cells, the compound binds to the NNMT active site, preventing the enzyme from converting nicotinamide to 1-MNA

They support red blood cell production, DNA synthesis, and normal nerve function when deficiency is present

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Because of this targeted structure, it is discussed in research in the context of fat metabolism rather than the broader effects of full growth hormone