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Experiments using purified human VDAC2 reconstituted into artificial liposomes confirm that erastin can bind this target and modulate transport flux [27]

Furthermore, while the siRNA-mediated knockdown of YTHDF1 provided valuable initial evidence for its role, we acknowledge the inherent limitations of siRNA technology, such as potential off-target effects and incomplete knockdown efficiency

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Liver cirrhosis, a frequent complication resulting from MASH, is not only the leading cause of HCC but also the second most common indication for liver transplantation in the USA [11]