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By modifying drug size, surface properties, and hydrophobicity, nanotechnology enables more efficient drug delivery, allowing for targeted transport and precise controlled release

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Trimethylamine N-oxide (TMAO), a metabolite derived from GM, exhibits an inverse relationship with BMD and a direct correlation with the occurrence of osteoporotic fractures in patients with type 2 diabetes mellitus (T2DM) ( Figure 1 , Table 1 )

In both structures Pro54 of each subunit is in the cis conformation