Here, we explored mainly the posttranslational regulation of GPX4 since its protein levels decrease more rapidly than its RNA levels (Fig
7(1132) Townsend, L., A.H
The authors would like to thank Shandong Academy of Medical Sciences for providing us with rabbit serum
In macrophages, the activation of mGluR5 elevates the level of the nuclear receptor peroxisome proliferator-activated receptor (PPAR) g and promotes a shift from M1 to M2 phenotype, leading to reduced IFN- production [180]
Sources: Sonthalia et al., 2018 , Narrative review, 2025 Precautions before treatment Disclose your full medical history, medicines and supplements Get a personalised dose and route from a qualified doctor Avoid if pregnant or breastfeeding Flag any known allergies or sensitivities Self-medication or IV use without medical supervision can pose serious health risks
Future studies aimed at mapping the interaction interfaces and identifying context-specific partners of CYP51A1 may offer new opportunities for therapeutic intervention
