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146 Sapidolide A, extracted from a folk medicine used in China to treat inflammatory diseases, inhibits expression and activation of the NLRP3 inflammasome when used as a pretreatment in a mouse model of APAP-induced liver injury

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When activated, this master regulator and its target genes attenuate numerous processes involved in neurodegeneration, including oxidative stress, neuroinflammation and mitochondrial dysfunction