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Curr Protoc Pharmacol
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A negative association of the levels of GSH levels with apoptosis of T lymphocytes, CD4 + , CD8 + T lymphocyte sub-sets and intracellular activated caspase-3 may support the role of reduced glutathione in the alteration of T lymphocyte apoptosis in the disease state [49,100]
Such oxidative thiol modifications lead to a change in the structure of proteins and cause either their activation (e.g., in hRas-Cys-118 [70] and mitochondrial glutathione S-transferase [71]) or inactivation (e.g., in phospho-fructokinase [72] and nuclear factor kappa B (NFB) [73])
