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Tissue NAD+ levels fall progressively across the lifespan

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High-dose oral supplements (often 10002000 micrograms daily) or intramuscular injections (typically 1mg hydroxocobalamin) used to treat pernicious anaemia or deficiency states can temporarily elevate serum levels

10.1016/j.freeradbiomed.2005.03.030 275 PottierC.BieniekK