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Small-molecule inhibitors such as MCC950 have shown efficacy in inhibiting NLRP3 activation and ameliorating liver injury in experimental models of APAP overdose

While certain functionalities can be achieved by directly modifying functional groups on the peptide sequence, this alteration may inevitably impact the primary role of the stapled peptide as a ligand in PPIs, mainly due to steric hindrance and other factors

( Clinical studies have confirmed elevated iron content specifically in coronary plaques from patients with acute coronary syndrome compared to stable coronary artery disease ( 5.3.2 Protection against ferroptosis in ischemic myocardium after coronary events Following coronary artery occlusion, the resulting myocardial ischemia-reperfusion injury involves extensive ferroptotic cardiomyocyte death

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Environ Geochem Health 45(12):99259940