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From the several sites that can generate superoxide in the mitochondrial matrix, only the superoxide produced at complex III appears to be released both into the matrix and the IMS (Quinlan et al., 2013)

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It is important to take into consideration that though intravenous glutathione is considered to increase its efficacy, it can also pose the risk of overdosing and toxicity (3)

F.CorraM.et al (2009)

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Y., Henrique-Bana, F