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However, it is important to note that clinical translation of these approaches does face several challenges: profound metabolic and molecular heterogeneity between patients (and even within tumors), difficulties in achieving adequate drug penetration across the blood-brain barrier, and the risk of toxicity in normal cerebral tissue

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Indeed, in several studies it has been proposed that GST polymorphisms may be used as biomarkers for prognosis in cancer patients 39,45

The instructions for how to do an injection were easy to understand