ITCs are electrophilic compounds that have been shown to activate phase II detoxification enzymes, including glutathione S -transferases (GSTs), in several organisms 24,25,26
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Free Radical Research, 32(3), 189-198
Treatment with combinations of channel blockers, tariquidar (10 M) and Ko143 (10 M), resulted in increased adult worm killing compared to treatments without channel blockers (Table 3)
1 Gclc is expressed in non-epithelial cells, and its loss in tumors does cause redox or metabolic alterations
It binds to toxins and heavy metals, facilitating their elimination from the body