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The high homocysteine level in LA most likely reflects its proatherogenic role in the pathogenesis of stroke, and may also explain the increased levels of cysteine and GSH in plasma, since a significant part of homocysteine is converted to cysteine, and the latter, in turn, is required for the formation of GSH

In addition, a newer class of drugs called sodium-glucose cotransporter-2 (SGLT2) inhibitors demonstrated cardioprotective properties in trials with individuals who have diabetes and CKD, as well as people with CKD who do not have diabetes

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& Hoek, J