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All TLRs, whether localized on the plasma membrane or within intracellular vesicles, share a conserved structural organization: an N-terminal domain containing leucine-rich repeats (LRRs), a single transmembrane (TM) helix, and a C-terminal cytoplasmic Toll-interleukin-1 receptor (TIR) domain

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220 European Committee for Standardization (CEN) and European Committee for Electrotechnical Standardization (CENELEC) Focus Group on Organ on Chip (FGOoC)