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Clinical studies utilizing facial application of 2-3% GHK-Cu serums over 12-week periods have documented measurable improvements across multiple photoaging parameters, including 20-35% reductions in fine line depth, 15-25% improvements in skin elasticity measurements, and 25-40% increases in dermal density as assessed through high-frequency ultrasound imaging

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Subsequently, the STAT3/SMAD3 complex was translocated into nuclei where the SMAD3-dependent transcription induced the cellular senescence of HMEC cells

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