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Ultimately, while CQDs represent a highly versatile and multifunctional nanoplatform, their translational success will depend on systematic validation, standardised manufacturing, and stronger integration between fundamental research and clinical application [103]

Finally, there is no evidence in humans that exogenous lipoic acid can be 'activated' with ATP or GTP and incorporated into lipoic acid-dependent enzymes by a lipoyl transferase (14)

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Rep 2016, 6, 19348 10.1038/srep19348

Reduction in oxidative stress markers is a measure of efficacy of GSH replenishment

This is referred to as tolerance. In addiction or misuse, tolerance also occurs and as a result, the person will tend to increase the dose or frequency