Given that GPR146 is most highly expressed in mature adipocytes, obesity-associated changes such as increased immune infiltration and stromal remodeling may reduce the relative abundance of GPR146-expressing cells in bulk tissue profiles
Furthermore, sulforaphane-treated CIA mice presented reduced levels of type II collagen-specific IgG, IgG1, and IgG2a antibodies in the circulation, confirming that sulforaphane inhibited B-cell differentiation into antibody-producing plasma cells in a context that also inhibited proinflammatory cytokine production
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