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Storage and disposal of compounded sterile preparations

doi: 10.1038/nm.3432 15 Dominguez-VillarMHaflerDA

A therapeutically useful arginine depleting agent for cancer treatment should have low toxicity, non-immunogenic (to prevent antibody production and allergic reactions) and fast-acting (to delay emergence of drug resistance) with long circulation half-life (to achieve sustained arginine depletion)

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eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues