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Safety, Side Effects & Regulatory Notes Early research suggests BPC-157 is well-tolerated in animals and limited human studies, but long-term effects remain unknown

Treatment with a single antibiotic does not yield the desired results, so most often dual antibiotic therapy is implemented, along with drugs that reduce hydrochloric acid secretion

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In fact, apart from ensuring direct access through the mucin, it was this recognition (of such a low 2-3uM solubility for niclosamide at neutral pH), that went into the initial thinking (see Supplemental Information S1 ) and prompted the invention and development of a niclosamide solution as opposed to any microparticle formulation that were all explored in the series of provisional patents (48)