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It accelerates re-epithelialization, supports stem cell differentiation, and improves recovery in aged or damaged tissues through increased microvessel density and modulated inflammatory pathways (e.g., NF-B and MAPK)

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Etiologic Factors of Gastroesophageal Reflux Disease Motility disorders Transient lower esophageal relaxationsa Weak lower esophageal sphinctera Weak esophageal peristalsis Etiology Gastroesophageal reflux results from several factors that lead to symptoms or injury of the esophageal mucosa by reflux of corrosive material from the stomach (Box 1.1)