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however, dedicated cardiovascular outcome trial (CVOT) data have not yet been published, and cardiovascular benefit has not been demonstrated Phase 3 trials are ongoing

For the supplementation of Folic B12

Oral methylcobalamin for everyday energy support Research has shown that high-dose oral B12 even in people with some absorption challenges can achieve adequate blood levels through passive diffusion, a secondary absorption pathway that doesn't depend on intrinsic factor

The key isnt to avoid B12 its just to be smart about how you use it

It may lead to symptoms such as tingling, numbness, and muscle problems

This method is common in animal models to study systemic or localized but deeper tissue effects