A case-control study
The theoretical synergies described are based on component mechanisms rather than validated combination studies
For inflammatory bowel disease, mesalamine, corticosteroids, immunomodulators (azathioprine, methotrexate), and biologics (infliximab, adalimumab, vedolizumab, ustekinumab) all have Level 1 evidence from Phase III trials with thousands of patients
Without it, B12 cant be taken into your bloodstream, regardless of how much you consume through your diet or oral supplements
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Cass AE, Hill HA