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All statins are administered in active hydroxy acid forms, except simvastatin and lovastatin, which require in vivo biotransformation from their lactone prodrug forms to exert pharmacological effects (Vickers et al., 1990

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For HUVEC and HDMEC, plates were pre-coated with gelatin (Difco Laboratories, 0.1% for 1 h at 37 C)

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