Taken together, these observations underscore how astrocytic metabolic and transporter dysfunctions underlie synaptic dysregulation and BBB disturbances in neurodegenerative diseases
By bypassing the digestive system, IV therapy ensures that nutrients are delivered directly into the bloodstream, allowing for immediate and efficient uptake by cells and tissues
These data were confirmed by a lower TEER in Ussing chambers (81, 82) and a decreased number of tight-junction strands shown by freeze-fracture electron microscopy (83)
A novel HDAC/MIF dual-target inhibitor (6a) at a concentration of 12.5 M promotes apoptosis by inhibiting HDAC activity and inducing histone acetylation (H3K27ac), while simultaneously blocking the MIF-CXCR7-AKT signaling pathway, thereby synergistically inhibiting the survival and proliferation of NSCLC cells (especially EGFR-mutant/TKI-resistant strains)
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PMID: 37658670 iScienceZebrafish functional xenograft vasculature platform identifies PF-502 as a durable vasculature normalization drug
