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In vitro experiments and in vivo studies employing animal models have demonstrated that SCFA supplementation elevates the transcriptional expression of TRPV6 and calbindin-D9k in both human colonic epithelial (Caco-2) cells and the colonic mucosa of rats (108, 185)

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Furthermore, in acquired models of 5FU resistance that show mitochondrial dysfunction, combination of ETC CI inhibition (by metformin and others) and 5FU treatment increased tumour control