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As emphasized by Zhao et al., the prolonged progression of AD before clinical symptoms emerge indicates that astrocytes may substantially contribute to disease pathogenesis at a single-cell resolution 12

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Yaeger R, Uboha NV, Klempner SJ, Bekaii-Saab TS, Sabari JK, Barve MA, Saltzman JN, Peguero JA, Paulson AS, Jnne PA, Pelster M, Cruz-Correa M, Kim AMK, Hu N, Ahmad HA, Kopetz S

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Tardif I, Gunette L, Zongo A, Demers , Lunghi C

Some companies are working on improved amyloid targeting with the aim of greater efficacy and fewer side effects