Studies conducted on MRP1-transfected NIH3T3 mouse fibroblasts with minute GSTP1-1 levels, TLK199 showed significant inhibition of ATP-dependent efflux and resulted in the enhanced retention and subsequent reversal of numerous resistant phenotypes including doxorubicin, daunorubicin, etoposide, mitoxantrone and vincristine [101]
other compliance monitoring is stressed for varied product quality and bioactive content can greatly affect safety and efficacy (237)
For more noticeable changes, a consistent series of treatments is recommended
Evidence type: Human RCT | Observational | Animal | In vitro | Regulatory Mechanism of Action As a copper chelator, GHK-Cu modulates over 4,000 human genes, upregulating those involved in tissue remodeling (e.g., collagen I, III) and downregulating pro-inflammatory pathways like NF-B
1995, New York: McGraw-Hill, 749-795
Sartippour et al., 2006)