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Oxidative stress (OS) is characterized by an imbalance between oxidation and anti-oxidation mechanisms (enzymic and non-enzymic antioxidants), leading to an increase in oxidation intermediates such as reactive oxygen species (ROS) (5)

In terms of mechanism, the cross-talk between IGF1R and carcinogenic factors, including integrins, focal adhesion kinase, and the RACK1 scaffolding protein enhanced the motility and migration of cells (Tressler et al., 1993

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(Source 13) While there is still more to learn, animal studies on yellow food dyes (including Yellow 6) decreased glutathione-s-transferase enzymes as a marker of oxidative stress

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If you follow a vegan or vegetarian diet, it can be hard to get enough B12 as it's not naturally found in foods such as fruit, vegetables, or grains