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We repeated the experiment with young (23 months old) and middle-aged (1014 months old) mice and observed various cytokines that had lower concentrations in the bone marrow serum of young and middle-aged Mda5 -/- animals compared to controls (Supplementary Fig

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Mechanisms of Collagen Synthesis The collagen synthesis mechanisms involve several key pathways: MAPK/ERK Pathway Activation This pathway upregulates collagen gene expression and promotes fibroblast proliferation, creating the cellular foundation for tissue repair