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Sterile water for injection does NOT contain a preservative and should only be used for single-dose reconstitution, as it provides no protection against microbial contamination after the first needle puncture

In vitro hepatic models suggested that flavonoids and sulfur-containing compounds in garlic supplements might interfere with the activity of efflux drug transporters of the ATP-binding cassette (ABC) family, including P-glycoprotein, multidrug resistance protein (MRP), and breast cancer-resistance protein (BCRP), which function as ATP-dependent efflux pumps that actively regulate the excretion of a number of drugs limiting their systemic bioavailability

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Cortassa et al

as induced in the liver by paracetamol overdose, a major indication for the clinical use of NAC (Green et al., 2013)