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This period establishes the gene expression changes that drive collagen synthesis, inflammation reduction, and tissue remodeling

This epigenetic mechanism is consistent with the broader Khavinson framework for bioregulator peptides, which proposes that short peptide sequences (27 amino acids) can penetrate nuclear membranes and interact directly with DNA or chromatin-associated proteins to modulate tissue-specific gene expression

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doi: 10.1016/0304-4165(80)90321-9 38

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