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Published pre-clinical studies have used FOXO4-DRI to demonstrate that selective elimination of senescent cells in aged mouse models can improve a range of tissue function parameters including fitness, fur density, renal function, and liver function establishing the broader research principle that senescent cell burden contributes meaningfully to ageing tissue dysfunction and that its targeted reduction produces measurable functional benefits in experimental models

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42, 101091 10.1016/j.molmet.2020.101091 [DOI] [PMC free article] [PubMed] [Google Scholar] 86.Grice, B.A., Barton, K.J., Covert, J.D., Kreilach, A.M., Tackett, L., Brozinick, J.T.et al