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Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment

Finkel RS, Mercuri E, Darras BT, Connolly AM, Kuntz NL, Kirschner J, et al

Our data suggest that choline can promote liver health by maintaining cholesterol homeostasis.10 Choline induces glucose and insulin intolerance in Pemt(-/-) mice through modulating plasma glucagon and its action in liver.11 Choline supplementation decreased the concentration of liver triacylglycerol during the first 4 wk after parturition

It also directly stimulates mast cell degranulation and promotes the release of pruritogens including histamine and prostaglandins

keloid fibroblasts were prone to senescence following an ischemic stimulus, and FOXO4-DRI selectively induced the apoptosis of keloid senescent fibroblasts via p53-pS15 translocation from the nucleus to the cytoplasm

Maibach (Eds.) Marcel Dekker, New York