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No single canonical receptor binds the peptide with high affinity, and the systems-level pharmacology that defines the compound continues to be an active research question

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p 80% in most comparisons), and Eggers test indicated potential publication bias

However, standard IBS treatments are being applied, including dietary interventions, medications tailored to predominant symptoms (e.g., anti-diarrheals or laxatives), and psychological therapies such as cognitive behavioral therapy or gut-directed hypnotherapy