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However, recent animal studies have produced evidence that strongly suggesting that the severe physical and psychological stress of combat may produce conditions that disrupt the integrity of the BBB , allowing pyridostigmine to penetrate into the central nervous system and produce neurotoxic effects (Friedman et al, 1996

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Furthermore, it was observed that OHP decreased the expression of the two-pore domain K + channels (TWIK-Related K + Channel 1 (TREK-1) and TWIK-related arachidonic acid-stimulated K + channel (TRAAK)) in the DRG of rodents [107]

In glioblastoma, microglia are chronically exposed to immunosuppressive signals that support tumor progression

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