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In astrocytes, approximately 80% of the glutamate is converted into glutamine by two exergonic steps: (i) the -phosphate residue is transferred from ATP to glutamate, which gives rise to an energy-rich mixed acid anhydride, and (ii) NH3 substitutes the phosphate residue from the intermediate, and glutamine and free phosphate are produced

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Similar content being viewed by others Introduction Class I glutaredoxins (Grx) are glutathione-dependent thiol:disulfide oxidoreductases that reversibly convert a variety of low or high molecular weight disulfide substrates using the cysteinyl-containing tripeptide glutathione (GSH) as a reducing agent (EC 1.8.4.14) 1,2,3,4,5,6,7,8

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