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It is not a medicine and is not for human or veterinary use

KA is not only a complete agonist of KARs but also a partial agonist of AMPARs [54, 55]

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Editors Note (10/17/2025): This article was updated to clarify that Breakthrough T1D did not fund the Zimislecel trials and to provide other details about Zimislecels mechanism of action, intended recipients and clinical trial results.

The in vitro studies of these covalent inhibitors showed a prolonged inactivation of the GSTP1-1 in human non-small-cell lung adenocarcinoma cells, which served as lead compounds for the further development of potent inhibitors of GSTP1-1 in cancer