At the molecular level, the balance of anabolic and catabolic (protein degrading) processes is coordinated primarily by the phosphoinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)/Forkhead boxO3a (FOXO3a) pathway among others (Glass, 2005)
In HF, increased fission reduces ATP production, while in AD, impaired fusion affects synaptic mitochondrial function
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