Miller EF, Vaish S, Maier RJ (2012) Efficiency of purine utilization by Helicobacter pylori : roles for adenosine deaminase and a NupC homolog
10.1111/jocd.12462 J Cosmetic Dermatol
Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system
peaks during dose escalation, typically mild-moderate Diarrhea -- 10-20%, usually transient Constipation -- 8-15% Vomiting -- 5-15%, more frequent at higher doses Injection site reactions -- 5-10%, mild erythema and pruritus Decreased appetite -- 5-12%, related to mechanism of action Pancreatitis -- rare but monitored (as with all GLP-1/amylin agents) Gallbladder events -- cholelithiasis reported, consistent with rapid weight loss Trial data describes dose titration as central to tolerability -- the 16-week escalation protocol substantially reduced GI adverse events
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