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The pathological mechanisms of DOR that have been identified include processes such as apoptosis, autophagy, oxidative stress, mitochondrial dysfunction, ovarian angiogenesis, inflammation, immune responses, and microRNA regulation (Fig

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Thus, our comparative genomic analyses illustrate that the fundamental functions of antioxidants have resulted in gene conservation throughout the animal kingdom, paving the way for functional analyses on these enzyme families in diverse animal phyla

The research to date shows a relatively favorable safety profile in limited human studies, but long-term safety and large-scale clinical trials are lacking

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