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ROS disrupts tight junction proteins such as occludin, claudin, and ZO-1 through oxidative and post-translational modifications, including the oxidation of cysteine residues that destabilize disulfide bonds and protein interactions [167,168]
doi: 10.3390/pr13030625 159
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b,c , Hydroxylation at either C 3 ( b ) or C 4 ( c ) allows the incorporation of the heavy oxygen isotope at the corresponding positions
[DOI] [PMC free article] [PubMed] [Google Scholar] 134.Zhang M., Brewer A., Schrder K., Santos C.X.C., Grieve D.J., Wang M., Anilkumar N., Yu B., Dong X., Walker S.J., et al