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Pharmacological treatments address hormonal and metabolic derangements: metformin remains a cornerstone for insulin resistance and hyperinsulinemia, both improving ovulation and indirectly reducing insulin-induced ROS production [159]

670 Further advancements in fluorescence techniques have led to the common utilization of Frster Resonance Energy Transfer (FRET) and Bioluminescence Resonance Energy Transfer (BRET) sensors, both genetically encoded specifically for zinc