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Additionally, CYP51A1 interacts with 15 core enzymes in the cholesterol biosynthesis pathway, including HMG-CoA reductase (HMGCR), FDFT1, dehydrocholesterol reductases (DHCRs), sigma non-opioid intracellular receptor 1 (SIGMAR1), and squalene epoxidase (SQLE), further supporting its central role in maintaining lipid homeostasis [47]

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Indeed, several chemoprevention trials have reported that the reduction in biomarkers of cancer risk (e.g., aflatoxin-DNA adducts) following SFN intervention was predominantly observed in subjects with the GSTM1-null genotype (58)

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