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Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

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It plays a key role in cellular repair, collagen production, and overall skin and tissue health

4.3.3 Iron homeostasis disruption Cigarette smoke (CS) perturbs systemic and cellular iron homeostasis through several interconnected mechanisms: (1) Hepcidin Upregulation: CS exposure elevates hepcidin expression, which subsequently downregulates the iron exporter ferroportin (FPN)