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Y.KikuchiC.ZajaI.et al (2013)

Kim YS, Leventhal BL, Koh YJ, Fombonne E, Laska E, Lim EC, et al

Vitamin B12 Deficiency Chickens with vitamin B12 deficiency usually develop clinical signs associated with nervous system impairment, such as leg weakness and perosis

Do not exceed recommended daily intake

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Therefore, the System Xc GSHGPX4 axis constitutes a complete and finely tuned antioxidant defense chain ( via genetic knockout in various cell types, or directly targeting its active site with small molecule inhibitors like RSL3, consistently and efficiently induces typical ferroptosis (Wang L