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Common causes of B12 deficiency include poor dietary intake, certain medical conditions (such as pernicious anemia or gastrointestinal disorders), and the bodys decreased ability to absorb B12 with age

Only a few cases due to vitamin B12 have been reported in the literature

Thus, S = 1 for males, and for females, S = 1.8 for the average female E 2, consistent with the 80% choice above

The main reason why CHO cells have been most frequently reported in this conjunction may be because this cell type represents by far the most frequently used mammalian expression system for the industrial production of therapeutic glycoproteins (Kim et al., 2012)