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Some people naturally have more melanin, which may lead to stronger pigmentation or uneven tone

10.1093/nutrit/nuv111 40 MalobertiA.BossiI.TassistroE.ReboraP.RacioppiA.NavaS.et al (2021)

Mossel, E.C., Wang, J., Jeffers, S., Edeen, K.E., Wang, S., Cosgrove, G.P., Funk, C.J., Manzer, R., Miura, T.A., Pearson, L.D., Holmes, K.V

Mix brown sugar with fresh lemon juice and a bit of coconut oil

Additionally, oxidative stress significantly impairs RFC function: Low glutathione: Reduces RFC function ~20-40% High nitric oxide: Reduces RFC function ~35% Hyperglycemia: Reduces RFC function ~20-35% Even if you're taking Leucovorin, oxidative stress can prevent it from reaching your brain